The automation and innovative design of BUCHI’s new spray dryer significantly improve spray drying performance

“Spray drying can be tedious and difficult to optimize or replicate, as many parameters are not accessible to users,” says Mr. Marco Meuri, Business Area Manager at BUCHI Labortechnik. “The new S-300 Mini Spray Dryer lets you monitor, control and automate your process like never before to achieve repeatable powders with minimal effort. All parameters, such as spray gas, drying gas and pump speed are automatically regulated by the system. The instrument also monitors both outlet temperature and product temperature for ultimate protection of heat-sensitive samples.

The Mini Spray Dryer S-300 has been carefully designed to make the most of the operator’s time. The unique automatic mode of the Mini Spray Dryer S-300 enables a fully automated spray drying process, freeing up time for other tasks. Method programming options save considerable time by allowing users to save and repeat their analyses, even possible for a sample queue where one sample is processed after another. Data reports in different formats can be easily generated at the push of a button.

Remote control options add to the convenient operation of the new Mini Spray Dryer S-300. The system can be monitored and controlled with an app on any mobile device or computer for more flexibility and faster reaction times to any process changes.

“Operational safety and convenience were priorities for us when developing the Mini Spray Dryer S-300,” Mr. Meuri added. “With the Inert Loop S-395, users can safely handle samples containing organic solvents. Spray drying of mixtures of water and organic solvents is also made possible by the S-396 dehumidifier, which provides dry air and enables stable spray drying conditions.

Innovative system features have been added to ensure better reproducibility of the spray drying process. Sample loss is minimized thanks to a cyclone with a conductive coating that prevents the sample from sticking to the walls. The stainless steel spray drying nozzle is reinforced with a ruby ​​stone to further increase the reproducibility of the process. The new cyclone assembly simplifies system maintenance, as the cyclone can be easily disassembled and cleaned to also minimize the risk of cross-contamination.

The Mini Spray Dryer S-300 is the latest version of the popular BUCHI Mini Spray Dryers, which has been featured in thousands of scientific publications on pharmaceutical, chemical and food research. To protect existing scientific data, extra care has been taken to ensure that all results are reproducible between Mini Spray Dryer B-290 and Mini Spray Dryer S-300. Therefore, no research work done on the Mini Spray Dryer B-290 is lost when transferring to the Mini Spray Dryer S-300.

The Mini Spray Dryer S-300 completes an established family of BUCHI laboratory equipment for drying applications. With Encapsulator B-390 for active ingredient encapsulation, Nano Spray Dryer B-90 HP for handling very small samples with highest yields and Lyovapor™ L-200/L-300 for lyophilization At the laboratory scale, BUCHI’s drying range can be used for any R&D application requiring a highly efficient, versatile and reproducible drying process.