Study identifies new genes for fibromuscular dysplasia

Three new genetic variants that regulate gene expression in arteries are linked to fibromuscular dysplasia, an arterial disease that can have dangerous consequences for the heart and blood vessels, according to a new study. The results, published in Nature Communications by an international team of FMD experts from the United States and Europe, also confirmed the importance of a fourth genetic target that has already been identified as being involved in the disease. .

“We used to think that foot-and-mouth disease was a rare disease, but the current estimate is that it can affect more than 3% of the population,” said senior author and co-correspondent Santhi Ganesh, MD, associate professor internal medicine and human medicine. genetics and cardiologist at the Frankel Cardiovascular Center at the University of Michigan. Ganesh added: “It is essential that we continue this research to better understand the causes of foot-and-mouth disease. The disease primarily affects women in their prime, and the diagnosis often occurs after a dangerous cardiovascular complication such as severe high blood pressure, stroke, or heart attack. “

The researchers note that the genes identified suggest that the genetic basis of foot-and-mouth disease may contribute by altering the structure and function of vascular smooth muscle cells. Notably, the genetic findings indicated a correlation with several more common cardiovascular diseases that are often reported in tandem with foot-and-mouth disease, including high blood pressure, migraines, intracranial aneurysm, and subarachnoid hemorrhage. There was a negative correlation with atherosclerotic coronary artery disease, while no common genetics have been confirmed with ischemic stroke, which also commonly affects people with foot-and-mouth disease.

“The results provide new biological information on this intriguing disease and on genes and pathways for further study, with the aim of identifying therapeutic targets for foot-and-mouth disease,” said Nabila Bouatia-Naji, co-lead author and co-author of the research. The National Institute of Health and Medical Research of France, also known as INSERM and team leader at the Paris Cardiovascular Research Center. Ganesh and Bouatia-Naji’s team combed through data from genome-wide association studies of more than 1,500 cases of foot-and-mouth disease, comparing them to more than 7,000 control samples from participants without foot-and-mouth disease. The three new genes involved in foot-and-mouth disease are ATP2B1, LRP1 and LIMA1, while the fourth that has been confirmed is known as PHACTR1.

“This is the most comprehensive genetic investigation of foot-and-mouth disease to date, and it was made possible through the collective efforts of our international research teams,” noted Ganesh. (ANI)

(This story was not edited by Devdiscourse staff and is auto-generated from a syndicated feed.)


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