This is an exciting opportunity to join a large team working on a Wellcome Leap project to understand the evolution of tissue status over time in patients with triple negative breast cancer. The incumbent will perform a critical function by performing long-term imaging using advanced microscopy approaches to quantify organoid and tissue responses to chemotherapy. The incumbent will develop post-acquisition analysis pipelines to enable precise quantification of cell and tissue phenotypes over time and facilitate the integration of these datasets with data extracted from other imaging modalities. The incumbent will work with a large interdisciplinary team both at King’s and with our global partners to provide new information on TNBC tumor progression and help identify new biomarkers for personalized medicine approaches.
This position will be offered on a fixed-term contract of one year from the start date with a potential extension until September 29, 2024.
This is a full time position – 100% full time equivalent
- Performing Long-Term Fluorescence Microscopy Using Advanced Non-Commercial Instruments
- Development of image analysis pipelines for reconstruction and quantification of 3D images
- Help optimize imaging acquisition protocols to improve analysis
- Analyze the data and provide it in an appropriate format for later query and incorporation into the predictive algorithm development pipelines by other teams
- Work closely with other members of the Wellcome Leap team to achieve core project goals
The above list of responsibilities may not be exhaustive, and the incumbent will be required to undertake the duties and responsibilities that may reasonably be expected in the course and classification of the position.
Skills, knowledge and experience
1. BSc and PhD in the relevant field
2. Previous experience in the development of pipelines for 3D image reconstruction and quantitative image analysis
3. Previous experience in advanced fluorescence microscopy
4. Previous experience of imaging 3D spheroids or organoids
5. Previous experience working with non-commercial light microscopy approaches
6. Experience working in a multidisciplinary environment
7. Strong communication skills
8. Ability to write scientific papers and articles
9. Strong presentation skills
10. Good understanding of the different imaging approaches (including non-optical) applied to biological samples
1. Background of cancer cell biology
2. Experience in culturing and handling human cells
* Please note that this is a doctoral level position, but applicants who have submitted their thesis and are waiting to obtain their doctorate will be considered. In these circumstances, the appointment will be made at level 5, spine point 30 with the title of research assistant. After confirmation of the doctoral award, the job title will become a research associate and the salary will increase to grade 6.
The selection process will be done through an interview with a panel and a presentation.
This position is subject to occupational health approval.