We are seeking an enthusiastic postgraduate student with a PhD in Psychiatric Genetics or a related field, to work with the NIHR Maudsley BRC Biomarkers and Genomics Theme to develop methods and applications of polygenic risk scores in depression, psychosis, dementia and other psychiatric and neurological disorders. features.
We strive to be a diverse, open, welcoming and supportive research environment for all. Faculty-wide initiatives are supported by an active diversity and inclusion team. Our search groups are primarily from white backgrounds, and we especially welcome applications from people of any other race or ethnicity (eg, black, Asian, Latinx).
The successful candidate will analyze genetic and clinical datasets from local studies and external datasets, such as UK Biobank the Psychiatric Genomics Consortium. You will have the opportunity to work closely with other BRC researchers in collaborative studies. Specific projects include evaluating the clinical utility of polygenic scoring studies for psychiatric disorders, developing communication tools for polygenic scoring, identifying genetic predictors of treatment response and adverse events ( pharmacogenomics) and the evaluation of genetic heterogeneity by clinical and environmental factors. These studies will provide the next generation of psychiatric genomics studies to uncover the genetic contribution to disorder risk and treatment response.
You will report to Professor Cathryn Lewis, working closely with other BRC researchers. The NIHR Maudsley BRC and the SGDP Center strongly support the career development of postdoctoral researchers: you will have the opportunity to develop your independence and support in applying for a research fellowship. Experience in the analysis of genetic studies is required, with high level statistical and computer skills. Previous experience with psychiatric traits is not necessary.
This position will be offered on a fixed-term contract until December 31, 2023, with a likely longer-term extension.
This is a full-time position, but applications for a part-time position are welcome. Hybrid work and flexible hours possible.
• Perform genetic and genomic analyzes of mental health and neurodegenerative disease data
• Perform polygenic risk score analyzes and develop risk prediction models
• Engage in data management and preparation to support other BRC studies
• Conduct analyzes and write scientific publications arising from the research, serving as first author
• Work in collaboration with members of the BRC team, in particular within the SGDP Center
• Contribute to the supervision of MSc and PhD students
• Present the results of analyzes to team members and at scientific conferences
• Undertake reproducible analysis in an open science framework, developing analysis pipelines and using github repositories.
The above list of responsibilities may not be exhaustive and the post holder will be required to undertake the duties and responsibilities reasonably expected within the scope and classification of the post.
Skills, knowledge and experience
- PhD in psychiatric/statistical/behavioral genetics or a related academic field with a strong analytical component
- Excellent R and linux/unix programming skills with the use of github
- Experience in genetic data analysis and genome-wide association studies
- Previous analysis of clinical or epidemiological datasets
- Excellent attention to detail (e.g. in data management and reporting of results)
- Strong interpersonal and written communication skills, with the ability to discuss research findings and methods with audiences from different backgrounds
- Experience writing and publishing articles reporting genetic analyzes of clinical disorders
- Previous involvement in collaborative team science
1. Active interest in supporting a diverse research environment
2. Commitment to open science through reproducible analysis pipelines and a github repository.
3. Previous Mental Health Research Experience
Please note that this is a PhD level position, however applicants who have submitted their thesis and are awaiting their PhD will be considered. In these circumstances, the appointment will be in 5th year, spine 30 with the title of research assistant. Upon confirmation of the PhD award, the job title will change to Research Associate and the salary will increase to Grade 6.