Postdoctoral Research Associate in Radionuclide Imaging and Biology job with KINGS COLLEGE LONDON

job description

This postdoctoral position, funded by the EPSRC research program on the next generation of molecular imaging and radionuclide therapy (MITHRAS), aims to study the biological effects within a variety of cells radiolabeled with various PET radionuclides and to quantify zirconium-89-oxine radiolabeled cells. administered to animals for cell tracking purposes, using preclinical PET imaging.

This project comes against the background of the increasing likelihood of availability of whole body PET, which would have huge implications for the monitoring of cell therapies in particular. Whole body PET (TBP) would allow cell labeling with activities up to 40 times lower and could also allow longer term imaging. The main limitation of PET in tracking cells is the concern that long-lived radionuclides will impart a high radiation dose to labeled cells, with unknown effects on their behavior; the radiobiology of internalized or surface-bound radionuclides on cell survival and behavior is poorly understood.

This project would allow us to determine the upper limits of radiolabeling in these cells for a range of PET radionuclides and to determine the benefits of the reduction (by >1 order of magnitude) of the radioactivity load of the monitored cells achievable in the TBP, in a range of cell types for cell therapies (especially cells with high radiation sensitivity such as lymphocytes).

Experimental work covers radiochemistry, radiobiology, molecular biology, in vitro cell studies and in vivo preclinical PET/CT imaging. In this position, the successful candidate will work closely with Drs. Terry and Torres, as well as other members of the Department of Chemical Imaging and Biology and scientists from outside institutions and universities.

This is an exciting opportunity to join a dynamic multidisciplinary research group within one of Europe’s leading biomedical imaging centers with access to state-of-the-art synthesis and radiochemistry facilities. The Department of Chemistry and Imaging Biology is part of the School of Biomedical Engineering and Imaging Sciences, which has a wide range of clinical and small animal imaging modalities, supported by the equipment of state-of-the-art and basic facilities of King’s. Finally, we are committed to supporting the career of the successful candidate through assistance with scholarship applications, networking events, and conference attendance.

This position will be offered on a 24-month fixed-term contract. This is a full-time position – 100% full-time equivalent .

Main responsibilities

  • Plan and conduct high quality research in the biological characterization of a range of cells radiolabeled with a variety of PET radionuclides, including 89Zr.
  • Maintain accurate and complete records of experimental work.
  • Write scientific presentations and publications.
  • Attend all meetings of research groups and broader departmental groups, as directed by the PI.
  • In consultation with the PI, contribute to the training of junior staff.
  • Work with and maintain close ties between Principal Investigators at ICAB.
  • Proactively contribute to the team spirit of the school and center by collaborating and offering support to other team members and groups and the laboratory management team and by accepting their support.
  • Help maintain good laboratory discipline and safety practices and set a professional example for others.
  • Take responsibility within the team for maintaining specific equipment and training others in its use.
  • General management of the laboratory, proportional to the note.
  • The opportunity to participate in public engagement activities.
  • The opportunity to teach.

The above list of responsibilities may not be exhaustive and the post holder will be required to undertake the duties and responsibilities reasonably expected within the scope and classification of the position.

Skills, knowledge and experience

Essential criteria

1. First degree in biology (2.1 or above)

2. Doctorate awarded in radiobiology, biology, pharmaceutical sciences, radionuclide therapy, radionuclide imaging or radiochemistry

3. Experience in radiolabelling

4. Solid publication history in the field of radiochemistry, biology, molecular imaging or radiobiology

5. Holds or has held a Home Office license for animal work

6. Experience working with radiopharmaceuticals

7. Resourceful, creative and able to act on his own initiative

8. The ability to take individual responsibility for planning and undertaking own work, in accordance with scientific deadlines.

9. Ability to organize and prioritize work

10. Meticulous attention to detail in experimental design and execution is required

Desirable criteria

1. Engage in multidisciplinary research projects

2. Experiment in labeling cells with radionuclides

3. Performing in vitro tests

4. Performing in vivo studies

5. Presentation of results at conferences

* Please note that this is a PhD level role, however applicants who have submitted their thesis and are awaiting their PhD will be considered. In these circumstances, the appointment will be in 5th year, spine 30 with the title of research assistant. Upon confirmation of the PhD award, the job title will change to Research Associate and the salary will increase to Grade 6.

More information

If further information is required, please contact [email protected]

This position is subject to Disclosure and Barring Service and Occupational Health clearance.